She attended Mc Gill University in Montreal where she majored in Russian Literature.
Kirshner's paternal grandparents were Jews from Poland, her granparents were survivors of the Holocaust.
The book features original material from well-known comic and graphic artists including Joe Sacco and Phoebe Gloeckner.
She is best known for her role as Jenny Schecter on the cable TV series The L Word (2004–2009), and for her recurring guest role as Mandy on the TV series 24 (2001-2005).She also appeared in Wolf Lake with Paul Wesley and also starred in the comedy, Not Another Teen Movie.Kirshner was born January 25, 1975 in Toronto, Ontario, Canada. Kirshner was born and raised in Toronto, Ontario, the daughter of Etti, a teacher, and Sheldon Kirshner, a journalist who writes for The Canadian Jewish News.She and Beverly Polcyn were nominated for Best Kiss at the 2002 MTV Movie Awards for Not Another Teen Movie.In 2011, it was announced that Kirshner would be the face of Monica Rich Kosann's jewelry collection.On April 20, 2012, it was announced that Kirshner will join the new sci-fi series Defiance, as the role of Kenya.